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Antibiotic Protocol

Antibiotic therapy—also known as AP—is an approach to treating rheumatic diseases with low-dose oral antibiotics, usually an antibiotic in the tetracycline class, but occasionally a tetracycline antibiotic in combination with oral antibiotics in other classes (e.g., a macrolide) and/or IV (intravenous) clindamycin.


AP is based on the theory, pioneered by Dr. Thomas McPherson Brown, that rheumatic diseases have an infectious origin. This treatment approach is generally focused on slowly reducing the underlying infectious cause(s) in either a pulsed regimen (e.g., Monday, Wednesday and Friday, or M-W-F) or a daily regimen that is tailored to meet the patient’s needs.

For more information, please click the link below for the Road Back Foundation website.